Two-Step Synthesis of ?-Aryl-?-diazoamides as Modular Bioreversible Labels
نویسندگان
چکیده
?-Aryl-?-diazoamides were synthesized in two steps under mild conditions. This expeditious route employs Pd-catalyzed C–H arylation of N-succinimidyl 2-diazoacetate to obtain 2-aryl-2-diazoacetates, followed by aminolysis. The ensuing diazo compounds can esterify carboxyl groups aqueous solution, and the ester products are substrates for an esterase. broad scope synthetic enables continued development chemical biology.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c00793